Lyles, 27, is the reigning 100m world and U.S. champion, but had been seeking Olympic gold in the event to solidify the title of "World's Fastest Man." And he got it, now the clear holder of that title.
USA's Fred Kerley finished third and won the bronze with a season-best time of 9.81 seconds.
Watch all the action from the Paris Olympics live on NBC
Lyles did not compete in the 100m in the 2020 Tokyo Olympics after finishing seventh of eight runner in the Olympics trials final, according to NBC News. He really started to focus on the 100m last year and set his sets on gold in Paris.
Justin Gatlin in 2004 was the last American man to win the 100m Olympics. After that, it was Usain Bolt's race to lose in 2008, 2012 and 2016 when he won the three-peat.
Bolt holds the 100m Olympic record of 9.63 set in 2012 and the world record of 9.58 set in 2009.
Italy's Marcell Jacobs won the 100m in 2020 with a time of 9.80. He finished in fifth this time with a time of 9.85. The USA's Kenneth Bednarek, the third American competing in the 100m in Paris, finished seventh.
Lyles is still expected to compete in the men's 200m starting on Tuesday and the men's 4x100m relay starting on Thursday.
He is looking to become the first man since Usain Bolt to win the 100m and 200m in the Olympics and has had his eye on Bolt's 200m world record of 19.19 set in 2009. The last American man to do the 100m-200m double gold was Carl Lewis in 1984.
Lyles is expected to remain a force in track and field throughout at least the 2028 Los Angeles Olympics.
He signed an extension earlier this year with Adidas through the 2028 Games. Lyles' agency told NBC Olympics it's "...the richest contract in the sport of track and field since the retirement of Usain Bolt." Official terms of the deal were not released.
Usain Bolt holds the Olympic record time of 9.63 seconds, set in the 2012 London Games.
Noah Lyles' personal best in the 100m is 9.81 seconds.
Noah Lyles is expected to compete in the men's 100m, 200m, and 4x100m relay while in Paris.
Here's what is schedule likely looks like:
Men's 100m
The men's 100m preliminaries will stream here.
