More than 100million are expected to tune in for one of the biggest annual sporting events on the planet, which this year takes place at Allegiant Stadium in Sin City.
The 49ers will be out for revenge after that defeat in Super Bowl LIV, as one of the NFL’s most storied historic franchises seeks a sixth title that would put them level with the New England Patriots and Pittsburgh Steelers for the all-time lead.
San Francisco have not triumphed in the big game since way back in 1994, but well-marshalled by former ‘Mr Irrelevant’ Brock Purdy and featuring the likes of offensive weapons Christian McCaffrey, Deebo Samuel and Brandon Aiyuk, Kyle Shanahan and Co will feel that this could well now be their time, provided they eliminate the defensive mistakes that saw them need an epic comeback to defeat the Detroit Lions in the NFC Championship Game.
R&B legend Usher is providing the half-time show entertainment this year, following on from Rihanna in 2023.
TV channel and live stream: In the UK, fans can watch the Super Bowl live via NFL Game Pass on DAZN - where you can sign up for just 99p.
Live coverage is also available free-to-air on ITV1 and via both the ITVX app and website, with coverage beginning at 10:45pm GMT. The game itself is slated to start at 11:30pm GMT, which is 3:30pm local time and 6:30pm ET.
Tiesto pulls out of Super Bowl performance due to 'family emergency'
Super Bowl: Why the Taylor Swift effect is beyond NFL's wildest dreams
Adele says she won't be going to the Super Bowl after last year
Meet the fitness influencer defying stereotypes ageing